Among the toxic reactions of drugs, neurotoxicity is the most common one, while drugs that act on the nervous system are more prone to neurotoxicity. Such toxicity can occur during both the development and maturity stage of the nervous system. Therefore, neurotoxicity is also a common cause of discontinuation of drug development.
Nerve cells are so active that attacks on the nervous system by toxic substances can lead to serious consequences. To avoid such risks for patients as well as so much cost of time and money for drug developers, Creative Bioarray, with the assistance of a team of highly experienced experts in this field, now offers in vitro neurotoxicity assay services including high throughput microelectrode array and neurite outgrowth assay.
The growth of neurites in human neurons is critical in neuronal formation, development and remodeling of synapses, response to injury, and regeneration. Measurement of neurite outgrowth can be of use in the research, screening and validation phases of the drug discovery process. In addition, a neurite outgrowth assay can also be used for the detection of toxic neuropathies.
Creative Bioarray has developed a range of in vitro neurite outgrowth assays to identify and characterize compounds inducing neurotoxicity, neuroprotection, neuroregeneration, or modulating neurogenesis. The neurite outgrowth services include screen for neurotoxicity, investigate neuroprotective treatments, study pathways involved in neurodegeneration and measure neuronal differentiation in real time. Besides, a detailed control image is generated in order to help clients to visualize the parameters.
At present, the animal experiments commonly used to evaluate neurotoxicity are based on the evaluation of changes in neuroethology and neurotoxicology. However, animal experiments are time-consuming, labor-intensive, and costly. In contrast, in vitro experiments, which are relatively simple and time-saving with low cost, can reflect the mechanism of toxic effects and facilitate early screening of drugs.
“The more complicated the model of in vitro culture is, and the more similar the culture is to the original tissue, the closer the results of the experiment are to the results of animal experiments.” A senior scientist introduced, “however, the structure and function of the nervous system are very complicated. Many factors such as the interaction between cells, the interaction between different brain functional areas, and their coordination may play an important role in the process of neurotoxicity. Therefore, in vitro experiments are actually difficult if you are aiming at high level of accuracy and precision.”
Apart from the aforementioned, Creative Bioarray also provides other in vitro assays of hepatotoxicity, cardiotoxicity, nephrotoxicity and genotoxicity. Empowered by leading technology and years of experience in biomedical science, Creative Bioarray has achieved quantities of challenging cases for customers and won great reputations among global users. Further information can be found on https://www.creative-bioarray.com/.
About Creative Bioarray
Creative Bioarray is a biomedical company focused on professional cells and related products and services located in Long Island City, New York and serving labs and organizations globe widely. Creative Bioarray uniquely pioneers the comprehensive development of tissue, antibody, protein and cell array technology to efficiently analyze the concurrent expression and function of proteins involved in inflammation, angiogenesis, apoptosis, cell growth, and signal transduction.