Qvirus Platform, the division developed by Creative Biogene, is dedicated to providing reagents, kits, and services that help researchers explore questions about gene discovery, regulation, and function. With years of experience, Qvirus launched a powerful platform for Lentivirus, Retrovirus, Baculovirus, and Adeno-associated Virus (AAV), ect. Recently, Qvirus platform announced the release of its one-stop
Oncolytic Vesicular Stomatitis Virus Service for virus-related projects.
Based on Qvirus platform, Creative Biogene is able to design, engineer and produce the most effective oncolytic vesicular stomatitis virus products.
Recombinant VSV, in which the natural envelope G protein is replaced by an exogenous reporter gene (such as fluorescent reporter protein, luciferase or secreted alkaline phosphatase (SEAP)), even if there is no G protein and heterologous viral envelope protein, usually It can also be propagated from the buds of producing cells to be incorporated into virions, and recombinant VSV production services are also provided according to customer needs.
In addition, Creative Biogene has established a comprehensive VSV reverse genetics system, and has made many advances in precise editing of the viral genome. Reverse genetics (the establishment of a method to recover infectious recombinant viruses from cDNA) enables the use of genetic engineering of VSV to study all aspects of the virus life cycle, and to create rVSV that is more suitable for vaccine and oncolytic applications.
Pseudotyped viruses are defined as viral particles with other types of viral envelopes or host cell proteins with or without their own envelopes. With the help of these characteristics of VSV, a pseudotyped virus system has been established, in which the VSV G protein is completely replaced by other types of viral envelope proteins. Various types of pseudotyped viruses have been constructed on the Qvirus platform with heterologous viral envelope proteins and used to check virus entry, identify new virus receptors, conduct neutralization tests, and use them as vaccine vectors. The application field of oncolytic vesicular stomatitis virus service include gene delivery, neural tracking research, development of vaccine vectors and gene therapy.
"Creative Biogene can provide customized, standardized, reliable and high-quality oncolytic virus therapy development services and products for global customers. Our services cover all aspects from virus engineering, virus verification to cell biology." said Marcia Brady, the marketing director of Creative Biogene, she also added, "In addition, various types of oncolytic virus engineering systems have been established internally to reduce budget and time to promote the development of oncolytic viruses."
About Qvirus Platform
Qvirus Platform, as a division of Creative Biogene, providing world-class packaging services for a variety of virus vector products. The expertise and years of experience have made Qvirus platform become a well-recognized industry leader in supporting the development of gene therapy and scientists worldwide.