Creative Biogene, one of the world’s leading biotechnology companies founded and driven by scientists, focuses on developing high-quality products and services to support the research in the field of genomics and molecular biology. With the support of an innovative portfolio of products and a custom-service-centered business model, Creative Biogene provides
oligonucleotide synthesis services for research on GMP-level oligonucleotide synthesis, modified oligonucleotides to high-throughput DNA or RNA oligonucleotide synthesis.
Oligonucleotides have a wide range of applications in biochemistry, biology, molecular diagnostics, genomics and other molecular biology experiments. Depending on its intended use, oligonucleotides can be unmodified or modified with various chemical moieties, for example, adding 5'or 3'phosphate groups to achieve connection or blocking extension, respectively, using radionuclides or fluorophores and/or a quencher label for use as a probe, the incorporation of thiols, amino groups or other reactive moieties enables functional molecules (such as enzymes) to be covalently coupled and extended with other linkers and spacers with different functions.
Creative Biogene has many years of professional and rich experience, and can provide a variety of synthesis scales, modifications and purifications to meet various needs, including sequencing, polymerase chain reaction (PCR), hybridization research, site-directed mutagenesis, microarray experiments, etc.
Creative Biogene's professional modified DNA oligonucleotide synthesis services include DNA oligonucleotides for synthesis (such as dU, dI), phosphorothioate, phosphorylation, spacers, amino linkers, thiols, biotin, digoxin, etc. modified with special bases. In addition, Creative Biogene can also provide DNA oligos labeled with fluorescent dyes and quenchers at 3', 5'or designated sites specified by customers.
Creative Biogene also provides customized mRNA synthesis services, which has attracted much attention due to its therapeutic potential in the field of gene therapy and regenerative medicine. With the development of in vitro transcription (IVT) methods, synthetic mRNA has become a new type of gene therapy. The IVT mRNA can be delivered exogenously to produce the desired protein in the cell. IVT mRNA will not integrate into the host genome and cause the transient production of the target protein. Since the intracellular process of protein expression is simpler, the risk of mutation and tumor development is minimized. Therefore, the use of IVT mRNA is particularly attractive for applications in regenerative medicine, vaccination, treatment of genetic diseases and tumors, and cell engineering. In addition, these in vitro transcripts can also be used in analytical techniques, structural studies, biochemical and genetic studies, and as functional molecules.
“As the world's leading biotechnology company, Creative Biogene can provide global customers with professional services for high-quality oligonucleotide synthesis.” said Marcia Brady, the marketing director of Creative Biogene, she also added, “With our unparalleled expertise and experience in oligonucleotide synthesis, Creative Biogene is confident to help you execute your specific project as cost-effectively and efficiently as possible without compromising quality. If you have any special requirements for our dsRNA synthesis service, please feel free to inform us of your needs.”
About Creative Biogene
Creative Biogene, as a top-of-its-kind company that holds a leading position and is committed to accelerating the development of human science through biotechnology, offering innovative technologies, products, unique tools and services for research discoveries and product development. With more than 10 years of experience and in-house experts, Creative Biogene has become a well-recognized industry leader to support researchers worldwide.