The development of mRNA will continue to revolutionize the field of biopharmaceuticals, and pseudouridine modification can improve mRNA technology and promote the development of mRNA drugs or vaccines. Recently, New York-based BOC Sciences announced that it has strengthened its supply of pseudouridine and its derivatives to meet the growing demand for mRNA development.
Unlike small molecule or antibody drugs, mRNA can guide cells to synthesize proteins that can be used as drugs or vaccines to prevent or fight diseases. Human mRNA is a single-stranded molecule that can carry DNA genetic information in the nucleus to the ribosome, and synthesize proteins through the process of translation. The development technology of mRNA has become a research hotspot in the field of biopharmaceuticals.
During the mRNA development process, some double-stranded RNA will be generated, which will cause a stress response and eventually lead to translation inhibition and mRNA degradation. Cells usually suppress the expression of exogenous mRNA, resulting in an inflammatory response. The strategy of using pseudouridine to modify mRNA can reduce or avoid the immune response, so as to achieve continuous and stable expression of exogenous mRNA in target cells. The incorporation of pseudouridine into mRNA not only protects the synthesized mRNA from the immune system, but also significantly enhances the ability of mRNA to express protein. Compared with mRNA without pseudouridine modification, the translation rate and stability of RNA with modification will be improved.
Pseudouridine modification is the most abundant RNA modification and generally results from the isomerization of uridine. Pseudouridine modification exists in tRNA, rRNA, snRNA and mRNA. The main function of pseudouridine modification is to change codons, enhance mRNA stability and reduce stress response.
Using pseudouridine derivatives to modify mRNA can also reduce the immune response caused by exogenous mRNA, and can even achieve better effects than pseudouridine modification.
The modification strategy of pseudouridine and its derivatives is an important technology in the development of mRNA drugs and vaccines. The modified RNA is more like an endogenous substance in the cell, thereby overcoming the natural immune response, maintaining stability, and improving translation efficiency.
For more information about pseudouridine and its derivatives, please visit the website: https://www.bocsci.com/pseudouridine-and-its-derivatives.html.
About BOC Sciences
BOC Sciences, as the world's leading supplier of pseudouridine with the largest production capacity, can meet customers' all-round needs from milligram to ton, from standard synthesis to custom synthesis. The company's annual output of pseudouridine exceeds 500 kilograms, satisfying the production from laboratory to industry. In addition to pseudouridine, it also provides pseudouridine derivatives to support the development of customer projects. The company has an experienced team and strict quality control system, and can supply pseudouridine and its derivatives with competitive prices and high quality. The packaging adapted to the characteristics of the product ensures the safety of transportation and the effectiveness of storage. The company has won the trust of pharmaceutical companies, biotechnology companies, laboratories and research institutions in more than 160 countries or regions around the world, and has established a good cooperative relationship with them.