As a New York-based CRO company, CD Formulation has keenly observed that the demand for tailored pharmaceutical excipients is on the rise, especially over the past decade, as each formulation project may need unique excipients. In response to such a market trend, the management of CD Formulation earlier this month announces to offer customized synthesis for lipid excipients, which are used in lipid-based dosage forms for the enhancement of drug absorption or delivery.
Although a number of technologies can help address formulation challenges, the lipid-based drug delivery system (LBDDS) is viewed as one of the most successful drug development approaches due to its competitive advantages for being able to solubilize hydrophobic compounds and also protect unstable compounds.
The fats or fatty acids used in the production of excipients are strictly derived from plant raw materials. Common lipid excipients are esterified products obtained by esterification of fatty acids and alcohols, such as glycerol polyethylene glycol, propylene glycol or polyglycerol, or vegetable oils.
Some Key Benefits of Lipid Excipients
l Dissolve drug in the formulation
l Keep the drug dissolved in the gastrointestinal tract
l Enhance the absorption of drugs and promote the penetration of drugs through intestinal epithelial cells
l Long-chain lipid excipients such as carbon chain 212 can promote drugs to enter the blood through lymphatic circulation
“Lipid-based formulations have helped bring more than 50 poorly soluble new chemical entities to the market. For researchers who need guidance on the development of lipid excipients, or need further information about product usage, routine and toxicological features, we are an appropriate choice,” says the Marketing Chief of CD Formulation. “Our laboratory and technical team would be glad to elaborate more and help push forward various drug formulation projects.”
In brief, the lipid excipients provided by CD Formulation can solve many problems that may exist in the drug formulation process, including but not limited to solubility, permeability, and regulation of drug release behavior.
The customized synthesis and manufacturing of lipid excipients can also be scaled up to commercial supplies. Please visit https://www.formulationbio.com/products/lipid-excipients.html to explore more.
About CD Formulation
Whole-heartedly dedicated to the drug formulation research, CD Formulation spares no effort to better and perfect its techniques and approaches. Via years of tireless innovation and knowledge building, the company is now positioned to bring new biologics such as lipids, peptides, and proteins into a solid oral dosage form. Constant progress made in excipient technology opens the possibility of LBDDS formulation. More potential applications are still there waiting for exploration. To this end, CD Formulation provides not only a series of preformation, formation and analytical services, but also tailored solutions to excipient manufacturing.