PROTACs (Proteolysis-targeting Chimeras), is a novel technique that induces targeted protein degradation through the ubiquitin-proteasome system that was first proposed by Crews et al in 2001. Biopharma PEG has developed some PEG derivatives which applied in PROTAC Linker.
The PROTAC molecule consists of three parts: a ligand that binds to a target protein, a ligand that recruits E3 ubiquitin ligase, and a linker (linker) between the two. The PROTAC molecule forms a stable triplet complex with the target protein and E3 ubiquitin ligase, which attaches the ubiquitin tag to the target protein, and the ubiquitinated target protein is recognized and degraded by the proteasome.
"PROTAC is a hot topic in recent years, PROTAC technology has attracted much attention, PEG is the most commonly used linker in PROTAC development", said the R&D director of Biopharma PEG, "According to statistics, most of the reported PROTAC molecules use PEG as linker. "
What are the benefits of PEG derivatives in PROTAC Linker?
1. The introduction of PEG can increase the water solubility of PROTAC molecule and affect the cell permeability, thus affecting the oral absorption.
2. By using PEGs with different chain lengths, the linker length can be easily changed systematically, which affects the degradation efficiency of PROTAC molecules.
3. Using various bifunctional PEG linkers, it is possible to assemble molecules with different linking groups simply and quickly, and accelerate the screening to obtain effective degradation structures.
About Biopharma PEG
Biopharma PEG Scientific Inc. is a biotechnology-oriented company in Watertown, Massachusetts. We are dedicated to manufacturing and supplying high purity monodispersed and polydispersed PEG derivatives, PEG raw material, PEGylation services, and custom PEG derivative synthesis to clients worldwide. As a leading manufacturer of PEG derivatives, Biopharma PEG is focused on the research and development of PROTAC Linker, providing high purity PEG Linker with various active groups, continue to help your research and development projects.
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Biopharma PEG Scientific Inc.
Address: 108 Water Street, Room 4D, Watertown, MA 02472, USA
TEL: 1-857-366-6766
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Email: sales@biochempeg.com
Website:https://www.biochempeg.com/