Cholesterol is a derivative of cyclopentane polyhydrophenanthrene. It is also the main steroid compound in mammals and plays an important role in basic cell life activities. Cholesterol mainly comes from the body's own synthesis, and cholesterol in food is a secondary supplement.
Cholesterol can regulate the fluidity of phospholipid bilayer membrane, reduce membrane permeability and reduce drug leakage. At the same time, it can maintain a certain flexibility of the lipid membrane and enhance the ability of liposome vesicles to resist changes in external conditions. And it has a certain protective effect on the oxidation of phospholipids.
Plant-derived cholesterol, as a new type of pharmaceutical excipient, can be used as helper lipids in lipid nanoparticle (LNP) formulations as it enhances particle stability by regulating membrane integrity and rigidity. It can be used for mRNA delivery, gene delivery and cell culture. Biopharma PEG is your trusted supplier of high-purity plant-derived cholesterol, whether it is an excipient in gene delivery, or an additive to promote cell culture media, it can meet your development needs.
"Over the past year, the demand for lipids (including cholesterol) has far outstripped supply. Biopharma PEG has responded quickly to this market demand by adding a new production line to meet the growing demand for cholesterol in pharmaceutical liposomal drug delivery" said the production director of Biopharma PEG. "We can provide customers with reliable price, high quality plant-derived cholesterol in large quantities."
Cholesterol is an important functional excipient for parenteral mRNA-based drug delivery systems. As part of the lipid coating that protects mRNA, cholesterol can modulate drug release, enhance the ability of drug formulations to penetrate cell membranes, and provides a stabilizing effect.
Biopharma PEG is a professional PEG derivatives supplier. It can also supply high-quality cholesterol (plant-derived) from lab to large scale to meet customers’ research and drug development needs.